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whereRU:
Information Visualization Gigapan project, the exterior of Alexander Library from the garage view. Visit http://whereru.rutgers.edu to see more Gigapans from the whereRU project. |
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Allison Road Classroom Building, Rutgers University. |
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On April 2, 2009, 1052 people at Rutgers University broke the Guinness World Record for the largest gathering of people dressed as Waldo. The event was held at the State Theater in New Brunswick, NJ.
Visit http://whereru.rutgers.edu to see more Gigapans from the whereRU project. |
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Group portrait of Alpha Sigma Phi Fraternity in at Rutgers.
For a truly unique Rutgers experience, visit http://whereru.rutgers.edu to see more Gigapans and Photosynths from the whereRU project. |
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"Moral Reasoning in Preschool Children" By Kasturi Mungale (kmungale@eden.rutgers.edu) In moral reasoning experiments, it was found that adults think harming someone as a means of saving 5 others is morally worse than harming someone as a foreseen consequence of saving 5 others. We hypothesized that preschoolers will have the same moral reasoning as adults in moral reasoning experiments; like adults, preschoolers will favor harming a person as a foreseen side-effect of saving 5 people rather than harming a person intended as a means to save 5 people. We presented 3-5 year olds with verbal narratives accompanied by computer animations involving a main character faced with a moral dilemma over whether to help 5 people by harming another person. Participants rated the main character?s actions on a 5 point scale from ?really bad? to ?really good?. Most of the preschoolers think that the foreseen scenario is ?really good,? the intended is ?really bad? and that omission is ?just okay?. Like adults, children rated scenarios in which harm was a foreseen side-effect as more permissible than harming a person intended as a means to save 5 people. These results show that preschoolers have the same moral reasoning as adults. It also shows that moral reasoning is not solely dependent on environmental and social factors. Since preschoolers have moral reasoning that is similar to adults, there maybe some unconscious processes that evaluate the intentions behind an action. |
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The Effects of RDH10 on Retinoic Acid Homeostasis in the Embryonic Tissues Stacey Chung, Youn-Kyung Kim, Lesley Wassef, and Loredana Quadro Department of Food Science and Rutgers Center for Lipid Research, SEBS, Rutgers University Retinoic acid (RA), the active form of vitamin A, is generated from retinol (vitamin A alcohol), through two oxidative steps. Normal embryogenesis is achieved by maintaining RA homeostasis in the developing tissues. The enzymes LRAT, Cyp26A1, RALDH2, and Stra6, which control tissue retinoid storage, catabolism, synthesis and uptake, respectively have been shown to play a crucial role in maintaining normal levels of RA in the embryo. Retinol dehydrogenases (RolDHs) are a family of enzymes that catalyze the conversion of retinol into retinal. Among the numerous enzymes included in this family, only RDH10 has been shown to be essential during embryogenesis. Indeed, embryos lacking this protein, are abnormal and display the typical features of embryonic vitamin A deficiency (1).We propose to investigate whether RDH10 contributes to maintaining RA homeostasis in the developing tissues. Mice lacking both LRAT, the enzyme that allows the formation of retinoid stores, and RBP, the sole specific transport of retinol in the circulation, (LRAT-/-RBP-/-) will be used, as this mouse strain is highly dependent on maternal dietary vitamin A intake to support normal embryonic development (2). To establish whether RDH10 contributes to maintaining embryonic RA homeostasis, we performed RT real-time PCR analysis to measure the mRNA expression levels of RDH10 in LRAT-/-RBP-/- embryos from dams fed diets with different vitamin A content during pregnancy. Wild-type embryos from dams under similar dietary regimens were used as control. 1.Sandell, L., et al. (2007) Genes and Development. 21:1113-1124 2. Kim, Y., et al. (2008) Journal of Biological Chemistry. 283:5611-5621 Advisor: Dr. Loredana Quadro http://foodsci.rutgers.edu/quadro/research.html Aresty Research Assistant: Stacey Chung (stchung@eden.rutgers.edu) |
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Breast cancer is the second leading cause of cancer death in women, exceeded only by lung cancer. The chance that breast cancer will be responsible for a woman's death is about three percent (1 in 35 women). Recent studies have shown that there is a link between suboptimal fetal conditions and a variety of diseases, including breast cancer. Alcohol exposure in utero creates a suboptimal fetal environment, and may increase breast cancer risk. In our lab, a rodent model has shown that alcohol exposure in utero increased susceptibility to mammary cancer in the offspring. We also saw an increase in estradiol levels (E2) in the animals exposed to alcohol in utero. Therefore, circulating estradiol may be involved in the increase in mammary cancer observed in the alcohol exposed rats. This study will focus on understanding the unknown mechanisms that may cause the increase in mammary cancer susceptibility. Insulin like growth factor (IGF) and epidermal growth factor (EGF) systems are important in the biology of mammary the gland as well as cancer etiology. Both EGF and IGF families are known to interact with one another, and the IGF system has been shown to cross talk with the estrogen receptor. Thus altered levels of E2 could alter IGF and EGF signaling. Therefore, we predict that alcohol consumption in utero alters fetal programming which causes altered E2, IGF, and EGF signaling in the offspring. Presented by Surein Theivakumar. Email: surein@eden.rutgers.edu |